H2BC1

Across TCGA patient cohorts, H2BC1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,494 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible H2BC1-associated genes across cancer lineages are DKC1, CDC25B, and ZNF629. Each is linked with H2BC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC1-to-partner and partner-to-H2BC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H2BC1 versus DKC1 in BRCA, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC1→partner) and Y-score (partner→H2BC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DKC1 →	+0.910	+0.724	.003	<.001	3	2
LUAD	CDC25B →	+0.959	+2.021	<.001	<.001	3	2
LUAD	ZNF629 →	+0.475	+1.429	.005	.001	3	2
PDAC	ESRP1 →	+0.477	+1.093	<.001	.004	3	2
LUAD	CNOT6 →	+0.449	+1.226	.002	.001	3	2
LUAD	SLC35F5 →	+0.375	+0.947	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,494 associations by consensus.

H2BC1 vs DKC1 — BRCA

Explore this scatter interactively →