H2BC1

Across TCGA patient cohorts, H2BC1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BC1-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and JNK2. Each is linked with H2BC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC1-to-partner and partner-to-H2BC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by H2BC1-low versus H2BC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC1→partner) and Y-score (partner→H2BC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.327	-3.459	.009	.005	3	1
UCEC	FoxM1 →	+0.272	+2.321	.036	.035	3	1
UCEC	JNK2 →	+0.234	+2.321	.019	.035	3	1
UCEC	Di-Ras3 →	-0.151	-2.321	.042	.035	3	1
UCEC	eIF4E →	+0.210	+2.321	.047	.035	2	1
UCEC	MEK1 →	+0.410	+2.321	.025	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by H2BC1 expression — UCEC

Explore this box plot interactively →