Across TCGA pan-cancer cohorts, H2AZP5 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of H2AZP5’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2AZP5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2AZP5 is over-expressed in tumor.
HNSC and LUSC are the cancer types where H2AZP5 tumor–normal differential expression is most reproducible.