H2AZ1-DT

Across TCGA pan-cancer cohorts, H2AZ1-DT RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated H2AZ1-DT data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher H2AZ1-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated H2AZ1-DT expression acts as an unfavorable survival marker, although some lineages such as ACC and SKCM show a favorable association.

ACC, LIHC, and BLCA are the cancer types where H2AZ1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	III,IV	0.587	0.107	.002	44	view →
LIHC	OS	Quartile	All	0.660	0.830	.004	37	view →
BLCA	OS	Tertile	IV	0.433	0.640	.007	24	view →
SKCM	DFS	Quartile	II,III,IV	0.375	0.204	.002	21	view →
CESC	DFS	Tertile	II,III,IV	0.423	0.692	.018	16	view →
KIRP	OS	Quartile	All	0.575	0.789	.015	15	view →
KIRC	DFS	Median	III,IV	0.302	0.568	.019	14	view →
BRCA	OS	Median	II,III,IV	0.887	0.935	.006	12	view →
THCA	OS	Tertile	All	0.980	0.995	.014	11	view →
MESO	DFS	Median	II,III,IV	0.262	0.638	.003	9	view →
GBM	OS	Tertile	All	0.309	0.516	.031	6	view →
COAD	DFS	Quartile	IV	0.283	0.627	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

H2AZ1-DT–ACC (DFS)

Open the ACC breakdown →