H2AZ1-DT

Across TCGA pan-cancer cohorts, H2AZ1-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of H2AZ1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2AZ1-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2AZ1-DT is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

HNSC, THCA, and LUSC are the cancer types where H2AZ1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2AZ1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.085	<.001	10	view →
THCA	Male	III,IV	−0.192	<.001	7	view →
LUSC	Male	II,III,IV	+0.204	<.001	6	view →
COAD	All	All	+0.144	.009	5	view →
STAD	All	All	+0.055	.004	5	view →
CHOL	All	All	+0.229	.002	4	view →
LIHC	All	All	+0.026	.002	4	view →
KIRP	Female	All	+0.234	.020	3	view →
BRCA	All	III,IV	−0.087	.012	2	view →
KICH	Female	All	−0.139	.048	1	view →
KIRC	All	IV	+0.134	.029	1	view →
LUAD	All	All	+0.075	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

H2AZ1-DT–HNSC

Open the HNSC breakdown →