Across TCGA patient cohorts, H2AX RNA expression is significantly associated with the protein abundance of many other proteins, with 21,352 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible H2AX-associated proteins across cancer lineages are NCL_S67, SMC2, and SMC4. Each is linked with H2AX in more than 9 cancer types. Because this analysis shows association rather than direction, both H2AX-to-partner and partner-to-H2AX results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AX→partner) and Y-score (partner→H2AX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCL_S67 →	+0.881	+0.738	<.001	<.001	3	10
LUAD	SMC2 →	+0.619	+0.943	<.001	<.001	3	10
LUAD	SMC4 →	+0.617	+0.896	<.001	<.001	3	10
LUAD	RRM2 →	+0.889	+0.952	<.001	<.001	3	10
LUAD	MKI67_S2528 →	+1.706	+1.076	<.001	<.001	3	10
LUAD	MKI67_S357 →	+1.567	+0.986	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,352 associations by consensus.

Exploration

H2AX survival (RNA) · tumor vs normal (RNA) · all H2AX data types