H2AW

Across TCGA patient cohorts, H2AW mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible H2AW-associated genes across cancer lineages are CCT3P1, MTND5P21, and RPEP6. Each is linked with H2AW in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AW-to-partner and partner-to-H2AW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT3P1 grouped by H2AW-low versus H2AW-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AW→partner) and Y-score (partner→H2AW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CCT3P1 →	+0.177	+6.289	<.001	.001	3	1
BLCA	MTND5P21 →	+0.100	+5.038	<.001	.009	3	1
BLCA	RPEP6 →	+0.082	+5.588	.005	.004	3	1
BLCA	MTND5P35 →	+0.051	+5.788	<.001	.003	3	1
BLCA	LINC02165 →	+0.120	+6.289	<.001	.001	3	1
BLCA	MIR3927 →	+0.772	+6.018	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

CCT3P1 by H2AW expression — BLCA

Explore this box plot interactively →