H2AW

Across TCGA pan-cancer cohorts, H2AW RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of H2AW’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where H2AW RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2AW is over-expressed in tumor.

KIRP, KICH, and COAD are the cancer types where H2AW tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2AW RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	+3.066	<.001	11	view →
KICH	Male	III,IV	+2.692	<.001	11	view →
COAD	Female	II,III,IV	+2.505	<.001	11	view →
THCA	Male	III,IV	+3.208	<.001	10	view →
KIRC	All	All	+0.635	<.001	9	view →
BLCA	Male	IV	+3.155	<.001	8	view →
LUSC	Male	All	+2.034	<.001	8	view →
LIHC	Female	All	+1.849	<.001	8	view →
LUAD	Male	All	+1.571	<.001	7	view →
HNSC	Male	All	+0.948	.001	7	view →
BRCA	All	II,III,IV	+0.892	<.001	6	view →
CHOL	Female	All	+5.246	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

H2AW–KIRP

Open the KIRP breakdown →