H2AW

Across TCGA cell cohorts, H2AW RNA expression is significantly associated with the go_rna of many other GO terms, with 4,390 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible H2AW-associated GO terms across cancer lineages are Muscle organ development, Negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, and Peptidyl-lysine oxidation. Each is linked with H2AW in more than 7 cancer types. Because this analysis shows association rather than direction, both H2AW-to-partner and partner-to-H2AW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Muscle organ development grouped by H2AW-low versus H2AW-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AW→partner) and Y-score (partner→H2AW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Muscle organ development →	-0.106	-1.984	<.001	<.001	3	8
BLOOD_Leukemia	Negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II →	-1.126	-2.044	<.001	<.001	3	7
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	-1.533	-2.798	<.001	<.001	3	7
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	-0.285	-2.587	<.001	.004	3	7
STOMACH	Oxaloacetate metabolic process →	+0.148	+2.244	<.001	.001	3	7
CNS	Cellular defense response →	-0.119	-1.335	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,390 associations by consensus.

Muscle organ development by H2AW expression — SOFT_TISSUE

Explore this box plot interactively →