H2AW

Across TCGA cell cohorts, H2AW mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H2AW-associated genes across cancer lineages are KCNA5, TBC1D21, and C12orf40. Each is linked with H2AW in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AW-to-partner and partner-to-H2AW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA5 grouped by H2AW-low versus H2AW-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AW→partner) and Y-score (partner→H2AW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KCNA5 →	+0.011	+4.095	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	C12orf40 →	+0.011	+4.684	<.001	.002	3	1
LARGE_INTESTINE	PFN3 →	+0.132	+4.467	<.001	.004	3	1
LARGE_INTESTINE	DEFA3 →	+0.076	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR13C7 →	+0.016	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

KCNA5 by H2AW expression — LARGE_INTESTINE

Explore this box plot interactively →