Across TCGA pan-cancer cohorts, H2AP Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated H2AP data layer compared with 11 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher H2AP Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated H2AP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, UCEC, and LUAD are the cancer types where H2AP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.040	0.912	<.001	36	view →
UCEC	DFS	Median	II,III,IV	1.000	0.435	.010	28	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: H2AP tumor-vs-normal RNA expression · all H2AP data types