H2AC8

Across TCGA pan-cancer cohorts, H2AC8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated H2AC8 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher H2AC8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H2AC8 expression acts as an unfavorable survival marker.

HNSC, LUSC, and DLBC are the cancer types where H2AC8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.200	0.647	<.001	24	view →
LUSC	DFS	Median	All	0.010	0.792	<.001	24	view →
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

H2AC8–HNSC (OS)

Open the HNSC breakdown →