H2AC8

Across TCGA pan-cancer cohorts, H2AC8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of H2AC8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2AC8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2AC8 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

HNSC, BLCA, and LUAD are the cancer types where H2AC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2AC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+2.549	<.001	12	view →
BLCA	All	All	+2.405	<.001	9	view →
LUAD	Male	All	+2.192	<.001	9	view →
LIHC	All	III,IV	+1.956	<.001	9	view →
LUSC	Female	II,III,IV	+2.421	<.001	8	view →
KIRC	All	III,IV	+1.006	<.001	8	view →
STAD	All	II,III,IV	+1.225	<.001	7	view →
UCEC	All	III,IV	+2.420	<.001	6	view →
BRCA	All	III,IV	+2.099	<.001	6	view →
CHOL	All	All	+1.936	.005	2	view →
PRAD	All	All	+1.113	<.001	2	view →
KIRP	All	All	+0.696	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

H2AC8–HNSC

Open the HNSC breakdown →