H2AC6

Across TCGA cell cohorts, H2AC6 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H2AC6-associated genes across cancer lineages are TNP1, OR10W1, and ABCG8. Each is linked with H2AC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AC6-to-partner and partner-to-H2AC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by H2AC6-low versus H2AC6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC6→partner) and Y-score (partner→H2AC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNP1 →	+0.214	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	ABCG8 →	+0.017	+4.191	.001	.007	3	1
BLOOD_Lymphoma	OR6B1 →	+0.017	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TNP1 by H2AC6 expression — LARGE_INTESTINE

Explore this box plot interactively →