H2AC6

Across TCGA pan-cancer cohorts, H2AC6 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated H2AC6 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher H2AC6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2AC6 expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

UCS, ACC, and MESO are the cancer types where H2AC6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	IV	0.302	0.817	.002	106	view →
ACC	DFS	Median	All	0.234	0.650	<.001	68	view →
MESO	OS	Tertile	All	0.558	0.265	<.001	67	view →
LGG	OS	Median	All	0.352	0.562	<.001	54	view →
PAAD	DFS	Quartile	All	0.241	0.530	.001	52	view →
COAD	OS	Median	All	0.832	0.901	.011	35	view →
KIRC	DFS	Median	All	0.737	0.488	<.001	28	view →
OV	DFS	Median	IV	0.591	0.336	.001	22	view →
READ	DFS	Quartile	II,III,IV	0.574	0.953	.003	21	view →
THYM	OS	Tertile	All	1.000	0.687	.003	18	view →
BRCA	OS	Tertile	IV	0.696	0.205	.021	17	view →
SKCM	DFS	Median	All	0.678	0.833	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

H2AC6–UCS (OS)

Open the UCS breakdown →