H2AC19

Across TCGA pan-cancer cohorts, H2AC19 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated H2AC19 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher H2AC19 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2AC19 expression acts as an unfavorable survival marker, although some lineages such as BLCA and ESCA show a favorable association.

UCEC, HNSC, and SARC are the cancer types where H2AC19 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	II,III,IV	0.652	0.803	.009	54	view →
HNSC	DFS	Tertile	All	0.519	0.712	.004	35	view →
SARC	OS	Tertile	All	0.367	0.539	.005	30	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	27	view →
THYM	OS	Tertile	III,IV	0.212	1.000	.014	18	view →
ACC	OS	Quartile	IV	0.339	0.780	<.001	18	view →
BLCA	DFS	Tertile	All	0.586	0.270	.038	12	view →
KIRP	OS	Tertile	II,III,IV	0.122	0.625	.035	9	view →
ESCA	DFS	Median	II,III,IV	1.000	0.399	.013	8	view →
KICH	DFS	Tertile	II,III,IV	0.363	0.803	.027	6	view →
MESO	OS	Tertile	All	0.409	0.222	.024	4	view →
SKCM	DFS	Quartile	IV	0.016	0.521	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

H2AC19–UCEC (OS)

Open the UCEC breakdown →