H2AC17

Across TCGA cell cohorts, H2AC17 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible H2AC17-associated genes across cancer lineages are GNG8, OR1L6, and KRTAP5-11. Each is linked with H2AC17 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AC17-to-partner and partner-to-H2AC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNG8 grouped by H2AC17-low versus H2AC17-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC17→partner) and Y-score (partner→H2AC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GNG8 →	+0.448	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.019	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	KRTAP5-11 →	+0.080	+4.887	<.001	.009	3	1
BLOOD_Lymphoma	SLC7A13 →	+0.003	+4.247	<.001	.004	3	1
BLOOD_Lymphoma	OR5AN1 →	+0.028	+3.765	.008	.001	3	1
BLOOD_Lymphoma	DEFB124 →	+0.108	+3.342	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GNG8 by H2AC17 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →