Across TCGA pan-cancer cohorts, H2AC11 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated H2AC11 data layer compared with 5 for mutation status.
The strongest signal is observed in small cell lung cancer (SCLC), where higher H2AC11 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated H2AC11 expression acts as an unfavorable survival marker, although some lineages such as SCLC and CESC show a favorable association.
SCLC, LGG, and PAAD are the cancer types where H2AC11 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.