Across TCGA pan-cancer cohorts, H2AC11 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of H2AC11’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2AC11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2AC11 is over-expressed in tumor.
HNSC, KIRP, and BRCA are the cancer types where H2AC11 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2AC11 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.