H2AB1

Across TCGA pan-cancer cohorts, H2AB1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated H2AB1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher H2AB1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H2AB1 expression acts as an unfavorable survival marker, although some lineages such as UCS and GBM show a favorable association.

COAD, LUAD, and CHOL are the cancer types where H2AB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.517	0.720	<.001	111	view →
LUAD	OS	Tertile	IV	0.263	0.728	.004	63	view →
CHOL	OS	Tertile	IV	0.024	0.732	.014	36	view →
UCS	DFS	Tertile	II,III,IV	0.784	0.359	.025	36	view →
KIRC	OS	Tertile	All	0.805	0.888	.006	24	view →
GBM	DFS	Tertile	All	0.482	0.228	.015	9	view →
LUSC	DFS	Tertile	III,IV	0.331	0.757	.043	9	view →
THYM	DFS	Tertile	III,IV	0.214	1.000	.008	9	view →
THCA	DFS	Quartile	IV	0.519	0.902	.019	6	view →
SKCM	OS	Tertile	II,III,IV	0.843	0.716	.049	3	view →
HNSC	OS	Tertile	II,III,IV	0.814	0.728	.044	3	view →
PCPG	DFS	Tertile	All	0.477	0.863	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

H2AB1–COAD (DFS)

Open the COAD breakdown →