H1-8

Across TCGA patient cohorts, H1-8 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,473 significant associations in total. STAD shows the largest number of these associations.

The most reproducible H1-8-associated GO terms across cancer lineages are Positive regulation of post-translational protein modification, Obsolete regulation of histone modification, and Positive regulation of DNA repair. Each is linked with H1-8 in more than 10 cancer types. Because this analysis shows association rather than direction, both H1-8-to-partner and partner-to-H1-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of post-translational protein modification grouped by H1-8-low versus H1-8-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-8→partner) and Y-score (partner→H1-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of post-translational protein modification →	+0.054	+0.053	<.001	<.001	3	11
STAD	Obsolete regulation of histone modification →	+0.049	+0.041	<.001	<.001	3	11
STAD	Positive regulation of DNA repair →	+0.051	+0.054	<.001	<.001	3	10
STAD	Regulation of DNA repair →	+0.053	+0.053	<.001	<.001	3	10
STAD	Spindle organization →	+0.062	+0.054	<.001	<.001	3	10
STAD	Mitotic spindle assembly →	+0.063	+0.049	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,473 associations by consensus.

Positive regulation of post-translational protein modification by H1-8 expression — STAD

Explore this box plot interactively →