H1-8

Across TCGA patient cohorts, H1-8 mutation is significantly associated with the RNA expression of many other genes, with 406 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-8-associated genes across cancer lineages are AP1B1P2, DUX4L46, and NPAP1P2. Each is linked with H1-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-8-to-partner and partner-to-H1-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP1B1P2 grouped by H1-8-low versus H1-8-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-8→partner) and Y-score (partner→H1-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AP1B1P2 →	+0.895	+6.087	<.001	.002	3	2
LUSC	DUX4L46 →	+0.166	+4.236	<.001	.008	3	2
SKCM	NPAP1P2 →	+0.026	+3.578	.001	.007	3	2
SKCM	RN7SKP126 →	+0.074	+5.219	<.001	.002	3	2
UCEC	TRIM49B →	+0.229	+2.281	.008	.004	3	2
UCEC	RNU7-128P →	+0.559	+2.315	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 406 associations by consensus.

AP1B1P2 by H1-8 expression — LUAD

Explore this box plot interactively →