H1-8

Across TCGA patient cohorts, H1-8 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-8-associated genes across cancer lineages are Stathmin, Cyclin-B1, and Di-Ras3. Each is linked with H1-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-8-to-partner and partner-to-H1-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by H1-8-low versus H1-8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-8→partner) and Y-score (partner→H1-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Stathmin →	+0.168	+3.000	.034	.037	3	2
UCEC	Cyclin-B1 →	+1.008	+3.000	.001	.037	2	1
UCEC	Di-Ras3 →	-0.213	-3.000	.013	.037	2	1
UCEC	4E-BP1 →	+0.500	+3.000	.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Stathmin by H1-8 expression — UCEC

Explore this box plot interactively →