H1-8

Across TCGA cell cohorts, H1-8 mutation is significantly associated with the mutation status of many other genes, with 966 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H1-8-associated genes across cancer lineages are VNN3, ECHDC1, and LZTS1. Each is linked with H1-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-8-to-partner and partner-to-H1-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VNN3 grouped by H1-8-low versus H1-8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-8→partner) and Y-score (partner→H1-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VNN3 →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	ECHDC1 →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	LZTS1 →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	NCKAP1 →	+3.159	+4.632	<.001	<.001	1	2
LARGE_INTESTINE	U2AF2 →	+3.007	+3.584	.008	.008	1	2
LARGE_INTESTINE	GLP2R →	+3.007	+3.584	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 966 associations by consensus.

VNN3 by H1-8 expression — LARGE_INTESTINE

Explore this box plot interactively →