Across TCGA patient cohorts, H1-6 protein abundance is significantly associated with the protein abundance of many other proteins, with 744 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible H1-6-associated proteins across cancer lineages are CDK12_S1082, EEF1D_S71, and RPS21. Each is linked with H1-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-6-to-partner and partner-to-H1-6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-6→partner) and Y-score (partner→H1-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDK12_S1082 →	+1.604	+1.890	<.001	.001	3	1
OV	EEF1D_S71 →	+1.635	+1.686	.001	.003	3	1
BRCA	RPS21 →	-0.178	-0.818	.001	<.001	3	1
BRCA	SNX3_S26 →	+2.205	+1.385	<.001	<.001	3	1
BRCA	SRSF2_S191 →	+0.882	+0.659	<.001	.008	3	1
BRCA	SYNJ1_S1345 →	+0.691	+0.954	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 744 associations by consensus.

Exploration

H1-6 survival (RNA) · tumor vs normal (RNA) · all H1-6 data types