Across TCGA patient cohorts, H1-6 mutation is significantly associated with the RNA expression of many other genes, with 594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-6-associated genes across cancer lineages are RNU6-753P, CKS1BP5, and RN7SL440P. Each is linked with H1-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-6-to-partner and partner-to-H1-6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-6→partner) and Y-score (partner→H1-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-753P →	+0.436	+4.890	<.001	.002	3	2
HNSC	CKS1BP5 →	+0.087	+4.424	.001	.008	3	2
HNSC	RN7SL440P →	+0.130	+3.916	<.001	.006	3	2
COAD	RNU6-605P →	+0.423	+5.283	<.001	.006	3	2
COAD	MIR3928 →	+0.971	+5.212	<.001	.007	3	2
HNSC	TFAP2D →	+0.356	+4.084	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 594 associations by consensus.

Exploration

H1-6 survival (RNA) · tumor vs normal (RNA) · all H1-6 data types