Across TCGA patient cohorts, H1-6 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-6-associated genes across cancer lineages are Syk, Tuberin, and c-Kit. Each is linked with H1-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-6-to-partner and partner-to-H1-6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-6→partner) and Y-score (partner→H1-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Syk →	+0.452	+3.013	.037	.019	3	1
UCEC	Tuberin →	+0.385	+3.009	.013	.019	2	1
UCEC	c-Kit →	-0.294	-3.000	.029	.037	2	1
UCEC	eEF2 →	+0.593	+3.000	.004	.037	1	1
UCEC	INPP4B →	-0.469	-2.986	.012	.037	1	1
UCEC	Annexin_VII →	-0.165	-3.000	.040	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

H1-6 survival (RNA) · tumor vs normal (RNA) · all H1-6 data types