Across TCGA cell cohorts, H1-6 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H1-6-associated genes across cancer lineages are WDR87, ACSM6, and XCR1. Each is linked with H1-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-6-to-partner and partner-to-H1-6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-6→partner) and Y-score (partner→H1-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR87 →	+0.016	+3.353	.002	.004	3	1
LARGE_INTESTINE	ACSM6 →	+0.020	+3.000	<.001	.005	3	1
LARGE_INTESTINE	XCR1 →	+0.290	+3.374	<.001	.005	3	1
LARGE_INTESTINE	SULT1C3 →	+0.818	+3.355	<.001	.007	3	1
SKIN	ODF4 →	+0.031	+4.977	<.001	.007	3	1
SKIN	DPPA5 →	+0.056	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

H1-6 survival (RNA) · tumor vs normal (RNA) · all H1-6 data types