H1-4

Across TCGA patient cohorts, H1-4 mutation is significantly associated with the RNA expression of many other genes, with 441 significant associations in total. STAD shows the largest number of these associations.

The most reproducible H1-4-associated genes across cancer lineages are LINC01148, OR5D17P, and MIR4733. Each is linked with H1-4 in more than 2 cancer types. Because this analysis shows association rather than direction, both H1-4-to-partner and partner-to-H1-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01148 grouped by H1-4-low versus H1-4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-4→partner) and Y-score (partner→H1-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC01148 →	+0.077	+5.106	<.001	.008	3	3
CESC	OR5D17P →	+0.042	+7.164	<.001	<.001	3	3
HNSC	MIR4733 →	+0.570	+5.912	<.001	.002	3	3
STAD	MICOS10P4 →	+0.338	+3.691	<.001	.008	3	3
BLCA	PRM3 →	+0.214	+6.289	<.001	.001	3	2
SKCM	RPSAP37 →	+0.031	+4.282	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 441 associations by consensus.

LINC01148 by H1-4 expression — BLCA

Explore this box plot interactively →