H1-4

Across TCGA pan-cancer cohorts, H1-4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated H1-4 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher H1-4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H1-4 expression acts as an unfavorable survival marker, although some lineages such as STAD and CESC show a favorable association.

KIRC, ACC, and ESCA are the cancer types where H1-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.533	0.731	<.001	160	view →
ACC	DFS	Median	All	0.381	0.772	<.001	126	view →
ESCA	OS	Tertile	All	0.629	0.861	<.001	89	view →
KIRP	OS	Quartile	All	0.455	0.833	<.001	54	view →
LGG	DFS	Median	All	0.324	0.486	<.001	39	view →
STAD	DFS	Median	III,IV	0.573	0.411	.004	27	view →
CESC	DFS	Median	II,III,IV	0.891	0.688	<.001	26	view →
SARC	OS	Median	All	0.748	0.897	.001	25	view →
DLBC	DFS	Quartile	All	0.939	0.442	.005	22	view →
THCA	OS	Median	IV	0.541	0.924	.004	22	view →
MESO	OS	Tertile	III,IV	0.380	0.625	.002	18	view →
LUAD	OS	Quartile	All	0.734	0.873	.002	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

H1-4–KIRC (DFS)

Open the KIRC breakdown →