H1-4

Across TCGA patient cohorts, H1-4 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-4-associated genes across cancer lineages are CD8+ T-cells, CD4+ Tcm, and CD8+ Tem. Each is linked with H1-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-4-to-partner and partner-to-H1-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by H1-4-low versus H1-4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-4→partner) and Y-score (partner→H1-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CD8+ T-cells →	+0.037	+5.177	.001	.007	3	1
BLCA	CD4+ Tcm →	+0.039	+4.527	<.001	.017	3	1
STAD	CD8+ Tem →	+0.008	+3.982	.009	.014	3	1
STAD	NK cells →	+0.002	+5.012	.043	.003	3	1
UCEC	MEP →	+0.042	+2.332	.002	.020	2	2
UCEC	Sebocytes →	+0.032	+3.032	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CD8+ T-cells by H1-4 expression — BLCA

Explore this box plot interactively →