H1-4

Across TCGA cell cohorts, H1-4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,783 significant associations in total. BONE shows the largest number of these associations.

The most reproducible H1-4-associated GO terms across cancer lineages are DNA strand elongation involved in DNA replication, Centrosome duplication, and Regulation of centriole-centriole cohesion. Each is linked with H1-4 in more than 9 cancer types. Because this analysis shows association rather than direction, both H1-4-to-partner and partner-to-H1-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation involved in DNA replication grouped by H1-4-low versus H1-4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-4→partner) and Y-score (partner→H1-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA strand elongation involved in DNA replication →	+0.139	+0.590	.004	.002	2	10
BONE	Centrosome duplication →	+0.093	+0.597	<.001	<.001	3	9
SOFT_TISSUE	Regulation of centriole-centriole cohesion →	+0.146	+0.724	<.001	<.001	3	9
BONE	Cell cycle phase transition →	+0.106	+0.637	.001	.001	3	9
BONE	Metaphase/anaphase transition of cell cycle →	+0.219	+0.690	.002	.001	3	9
CNS	Meiotic chromosome segregation →	+0.108	+0.455	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,783 associations by consensus.

DNA strand elongation involved in DNA replication by H1-4 expression — SOFT_TISSUE

Explore this box plot interactively →