H1-3

Across TCGA pan-cancer cohorts, H1-3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated H1-3 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher H1-3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H1-3 expression acts as an unfavorable survival marker.

COAD, SKCM, and BRCA are the cancer types where H1-3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.056	0.871	<.001	45	view →
SKCM	OS	Median	III,IV	0.111	0.814	<.001	18	view →
BRCA	DFS	Median	All	0.170	0.527	.012	10	view →
DLBC	OS	Median	All	0.053	0.936	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

H1-3–COAD (OS)

Open the COAD breakdown →