H1-3

Across TCGA pan-cancer cohorts, H1-3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated H1-3 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher H1-3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated H1-3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where H1-3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.699	0.858	.011	8	view →
PDAC	OS	Median	II,III,IV	0.290	0.433	.031	7	view →
LSCC	OS	Tertile	All	1.000	0.684	.025	2	view →
CCRCC	DFS	Tertile	All	0.989	0.841	.038	2	view →
LUAD	OS	Median	III,IV	0.764	0.985	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

H1-3–HNSC (DFS)

Open the HNSC breakdown →