H1-3

Across TCGA pan-cancer cohorts, H1-3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of H1-3’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where H1-3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types H1-3 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where H1-3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H1-3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	+0.876	<.001	11	view →
LUAD	Female	III,IV	−0.932	<.001	8	view →
LSCC	Male	II,III,IV	−0.598	<.001	4	view →
COAD	All	IV	+1.104	<.001	2	view →
PDAC	Male	IV	−0.560	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

H1-3–CCRCC

Open the CCRCC breakdown →