Across TCGA pan-cancer cohorts, H1-10-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated H1-10-AS1 data layer compared with 1 for mutation status.
The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher H1-10-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated H1-10-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and CESC show a favorable association.
PAAD, ACC, and STAD are the cancer types where H1-10-AS1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.