H1-1

Across TCGA pan-cancer cohorts, H1-1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated H1-1 data layer compared with 17 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher H1-1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H1-1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, BLCA, and UCEC are the cancer types where H1-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.090	0.812	<.001	24	view →
BLCA	DFS	Median	IV	0.083	0.476	.001	12	view →
UCEC	DFS	Median	All	1.000	0.630	.033	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

H1-1–LUAD (OS)

Open the LUAD breakdown →