H1-1

Across TCGA pan-cancer cohorts, H1-1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated H1-1 data layer compared with 17 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher H1-1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated H1-1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where H1-1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.923	0.395	.010	21	view →
HNSC	OS	Quartile	IV	0.596	0.956	.006	17	view →
CCRCC	DFS	Median	All	0.729	1.000	.005	5	view →
LUAD	DFS	Median	All	0.722	0.507	.048	1	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

H1-1–PDAC (DFS)

Open the PDAC breakdown →