Across TCGA pan-cancer cohorts, H1-0 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated H1-0 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher H1-0 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated H1-0 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where H1-0 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.984	0.502	.001	27	view →
CCRCC	OS	Median	IV	1.000	0.451	.016	12	view →
LUAD	DFS	Median	III,IV	0.332	0.716	.011	4	view →
HNSC	DFS	Median	II,III,IV	0.692	0.857	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: H1-0 tumor-vs-normal RNA expression · all H1-0 data types