Across TCGA patient cohorts, GZMM protein abundance is significantly associated with the RNA expression of many other genes, with 10,330 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GZMM-associated genes across cancer lineages are KRT17P8, MAP4K1, and CRTAM. Each is linked with GZMM in more than 5 cancer types. Because this analysis shows association rather than direction, both GZMM-to-partner and partner-to-GZMM results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMM→partner) and Y-score (partner→GZMM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KRT17P8 →	+1.012	+0.637	<.001	<.001	3	6
HNSC	MAP4K1 →	+1.389	+0.702	<.001	.001	3	5
BRCA	CRTAM →	+0.990	+0.958	<.001	<.001	3	5
HNSC	LY9 →	+1.067	+0.595	<.001	.005	3	5
HNSC	ZNF831 →	+0.997	+0.638	.001	.001	3	5
HNSC	CARMIL2 →	+0.798	+0.453	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,330 associations by consensus.

Exploration

GZMM survival (RNA) · tumor vs normal (RNA) · all GZMM data types