Across TCGA pan-cancer cohorts, GZMM RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GZMM data layer compared with 3 for mutation status and 5 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GZMM RNA is associated with better overall survival. In most high-consensus cancer types, elevated GZMM expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.
HNSC, UCEC, and CESC are the cancer types where GZMM RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.