Across TCGA patient cohorts, GZMM mutation is significantly associated with the RNA expression of many other genes, with 173 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GZMM-associated genes across cancer lineages are MIR6133, RNU6-147P, and CTHRC1P1. Each is linked with GZMM in more than 1 cancer types. Because this analysis shows association rather than direction, both GZMM-to-partner and partner-to-GZMM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMM→partner) and Y-score (partner→GZMM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6133 →	+0.415	+3.175	<.001	.002	3	2
COAD	RNU6-147P →	+0.486	+5.212	.002	.007	3	2
UCEC	CTHRC1P1 →	+0.123	+3.279	.001	.006	3	1
UCEC	SNORD116-4 →	+1.129	+3.300	.001	.008	3	1
UCEC	MIR6881 →	+0.429	+2.681	<.001	.008	3	1
UCEC	ZC3H18 →	+0.546	+3.354	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 173 associations by consensus.

Exploration

GZMM survival (RNA) · tumor vs normal (RNA) · all GZMM data types