Across TCGA cell cohorts, GZMM mutation is significantly associated with the mutation status of many other genes, with 748 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GZMM-associated genes across cancer lineages are ZNF511, KERA, and CELA2A. Each is linked with GZMM in more than 1 cancer types. Because this analysis shows association rather than direction, both GZMM-to-partner and partner-to-GZMM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMM→partner) and Y-score (partner→GZMM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF511 →	+4.824	+5.392	.004	.004	1	1
SKIN	KERA →	+4.239	+5.053	.007	.007	1	1
SKIN	CELA2A →	+5.824	+5.824	.002	.002	1	1
SKIN	PIK3R1 →	+5.824	+5.824	.002	.002	1	1
SKIN	FEZF2 →	+4.824	+5.392	.004	.004	1	1
BLOOD_Leukemia	TGOLN2 →	+4.321	+5.285	.005	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 748 associations by consensus.

Exploration

GZMM survival (RNA) · tumor vs normal (RNA) · all GZMM data types