GZMH

Across TCGA patient cohorts, GZMH protein abundance is significantly associated with the RNA expression of many other genes, with 12,174 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GZMH-associated genes across cancer lineages are GZMB, NKG7, and IFNG. Each is linked with GZMH in more than 7 cancer types. Because this analysis shows association rather than direction, both GZMH-to-partner and partner-to-GZMH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GZMH versus GZMB in UCEC, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMH→partner) and Y-score (partner→GZMH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GZMB →	+1.757	+0.844	<.001	<.001	3	7
UCEC	NKG7 →	+1.632	+0.806	<.001	<.001	3	7
UCEC	IFNG →	+1.538	+0.852	<.001	<.001	3	7
UCEC	ZAP70 →	+1.264	+0.799	<.001	.003	3	7
HNSC	CD48 →	+1.128	+0.854	<.001	<.001	3	7
UCEC	FASLG →	+1.249	+0.850	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,174 associations by consensus.

GZMH vs GZMB — UCEC

Explore this scatter interactively →