GZMH

Across TCGA pan-cancer cohorts, GZMH RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of GZMH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GZMH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GZMH is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, LUSC, and LUAD are the cancer types where GZMH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GZMH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+2.572	<.001	11	view →
LUSC	Male	II,III,IV	−2.003	<.001	8	view →
LUAD	All	II,III,IV	−1.319	<.001	8	view →
STAD	All	II,III,IV	+1.022	.027	5	view →
UCEC	All	All	−1.253	<.001	4	view →
BRCA	All	II,III,IV	−0.382	.013	4	view →
KIRP	Male	All	+0.984	.004	2	view →
LIHC	Male	All	−0.559	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

GZMH–KIRC

Open the KIRC breakdown →