GZMH

Across TCGA patient cohorts, GZMH mutation is significantly associated with the RNA expression of many other genes, with 497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GZMH-associated genes across cancer lineages are RNU6-621P, RARRES2P4, and MTND2P25. Each is linked with GZMH in more than 1 cancer types. Because this analysis shows association rather than direction, both GZMH-to-partner and partner-to-GZMH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-621P grouped by GZMH-low versus GZMH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMH→partner) and Y-score (partner→GZMH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-621P →	+0.410	+4.126	<.001	.004	3	2
COAD	RARRES2P4 →	+0.206	+4.321	<.001	.002	3	2
LUAD	MTND2P25 →	+0.039	+7.930	.001	.008	3	2
LUSC	RPS3AP1 →	+0.216	+5.417	<.001	<.001	3	2
UCEC	COX15 →	+0.639	+3.223	<.001	.009	3	1
UCEC	SLC7A11 →	+1.623	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 497 associations by consensus.

RNU6-621P by GZMH expression — COAD

Explore this box plot interactively →