GZMH

Across TCGA patient cohorts, GZMH mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GZMH-associated genes across cancer lineages are Ku80, MAPK_pT202_Y204, and p38-MAPK_pT180_Y182. Each is linked with GZMH in more than 1 cancer types. Because this analysis shows association rather than direction, both GZMH-to-partner and partner-to-GZMH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GZMH-low versus GZMH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMH→partner) and Y-score (partner→GZMH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.414	+2.179	<.001	.034	3	1
UCEC	MAPK_pT202_Y204 →	-0.779	-3.169	.001	.019	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.725	-3.169	.002	.019	3	1
UCEC	PKC-a →	+0.525	+2.820	.013	.035	3	1
UCEC	TSC1 →	+0.249	+3.321	.005	.010	3	1
UCEC	YB-1_pS102 →	-0.229	-3.321	.018	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by GZMH expression — UCEC

Explore this box plot interactively →