GZMH

Across TCGA cell cohorts, GZMH mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GZMH-associated genes across cancer lineages are OR5B17, OR5G3, and SCYGR1. Each is linked with GZMH in more than 1 cancer types. Because this analysis shows association rather than direction, both GZMH-to-partner and partner-to-GZMH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5B17 grouped by GZMH-low versus GZMH-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMH→partner) and Y-score (partner→GZMH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR5B17 →	+0.054	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR5G3 →	+0.030	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	SCYGR1 →	+0.534	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR5B17 by GZMH expression — BLOOD_Lymphoma

Explore this box plot interactively →