GZMA

Across TCGA patient cohorts, GZMA mutation is significantly associated with the RNA expression of many other genes, with 2,778 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GZMA-associated genes across cancer lineages are ENTR1, SLC3A2, and WDR76. Each is linked with GZMA in more than 2 cancer types. Because this analysis shows association rather than direction, both GZMA-to-partner and partner-to-GZMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENTR1 grouped by GZMA-low versus GZMA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GZMA→partner) and Y-score (partner→GZMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENTR1 →	+0.510	+2.923	<.001	<.001	3	3
UCEC	SLC3A2 →	+0.810	+3.290	<.001	<.001	3	3
UCEC	WDR76 →	+0.704	+2.906	<.001	.001	3	3
UCEC	RAD23A →	+0.445	+3.711	.005	<.001	3	2
UCEC	RCC1 →	+0.478	+3.633	.004	.001	3	2
UCEC	PRF1 →	+1.055	+2.606	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,778 associations by consensus.

ENTR1 by GZMA expression — UCEC

Explore this box plot interactively →