GYS2

Across TCGA cell cohorts, GYS2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GYS2-associated genes across cancer lineages are C5orf52, FAM205A, and LRRC3C. Each is linked with GYS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GYS2-to-partner and partner-to-GYS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by GYS2-low versus GYS2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GYS2→partner) and Y-score (partner→GYS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C5orf52 →	+0.065	+3.813	<.001	.001	3	2
LARGE_INTESTINE	FAM205A →	+0.025	+4.029	<.001	<.001	3	1
SKIN	LRRC3C →	+0.046	+4.054	<.001	.004	3	1
LUNG_NSCLC_LUAD	SERPINA4 →	+0.601	+4.569	<.001	<.001	3	1
LUNG_NSCLC_LUAD	BPI →	+0.243	+3.971	<.001	.004	3	1
LUNG_NSCLC_LUAD	FGF3 →	+0.312	+3.747	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

C5orf52 by GYS2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →